Carl Novina, M.D., Ph.D.

Dr. Novina is an Assistant Professor in the Department of Pathology at Harvard Medical School, an Assistant Professor of Cancer Immunology/AIDS at Dana-Farber Cancer Institute and an Associate Member at the Broad Institute. His research focuses on investigating the mechanisms and applications of mammalian RNAi. To discover the biological roles of microRNAs and their interacting proteins, his group has developed cell-free, microRNA-dependent translational gene silencing reactions and cell-based reporter systems for translational repression and mRNA cleavage by microRNAs. His laboratory is engaged in collaborative projects to profile microRNA expression as well as microRNA and RNAi factor gene loci, in an effort to understand the roles of microRNAs in cancer, including hematopoietic and solid tumors.

Dr. Novina received his M.D. from Columbia University, College of Physicians and Surgeons in 2000 and his Ph.D. from Tufts University, Sackler School of Graduate Biomedical Sciences in 1998. He did his graduate studies on transcriptional regulation of TATA-less promoters by TFII-I in Dr. Ananda Roy’s laboratory. Dr. Novina completed his postdoctoral training with Dr. Phillip Sharp, Nobel Laureate, at Massachusetts Institute of Technology investigating small RNA-directed gene silencing.